The 56-year-old 'Heaven Is a Place on Earth' singer has just got her motorcycle license in Los Angeles in preparation for the 1,135 mile journey.
"I'm doing a rickshaw ride in India in March from Kolkata to Udaipur," Belinda shared in a video shot in her LA living room with her pug Bam Bam.
"So why not make a donation in somebody's name this holiday season - that person who is impossible to buy for."
Carlisle has a fund-raising goal of USD 25,000 to help the Animal People Alliance (APA), which works to improve the lives of slavery survivors with economic empowerment and education strategies.
The charity helps to "train and employ vulnerable youth and women as veterinary technicians, dog handlers and animal caregivers" in India.
Fans of the singer can donate to get signed copies of Carlisle's studio albums, a Skype call from the star and a chance to ride the rickshaw with the singer on the last day of the journey.
The US singer will head to Rishikesh in the new year to undertake a Kundalini Yoga teacher-training course, before setting off on the West Bengal-to-Rajasthan trip. Donations can be made to Carlisle's fund-raising rickshaw trip across India.