The Bigg Boss 6 finalist was held after a woman filed a complaint of threat and sexual harassment against her and Ismail.
The police charged them with molestation and criminal intimidation.
“Actress Sana Khan and her boyfriend Ismail Khan were arrested under IPC sections 354 (assault or criminal force to woman with intent to outrage her modesty) and 506 (punishment for criminal intimidation) following a complaint by a woman," said Amboli police station's senior inspector Ramesh Khadtare.
The 'Jai Ho' actress Sana and her boyfriend Ismail Khan had on October 21 allegedly twisted the hands of the victim, touched her inappropriately and threatened her over an article which appeared in a newspaper last week.
The duo suspected that Khanna had leaked an information to the media because of which the article, which was against the two, had been published in the newspaper.
The incident had occurred in the accused's vehicle outside a hospital in suburban Andheri.
Sana has appeared in a range of South Indian movies and was last seen in Bollywood superstar Salman Khan’s Jai Ho.
Meanwhile, embroiling herself in another case, "Style" actor Sahil Khan registered a complaint with the Amboli police station.
According to Sahil, Ismail attacked him on October 22 alleging that he gave wrong news about Sana to the press.
"On Oct 22nd, I was gymming when Ismail attacked me. I didn't know how to react because I didn't know why he started hitting me. He started saying that you are jealous of Sana and you are the one who has given wrong stories about her to the press," Sahil told newsagency IANS.
"Actually few days back, some stories about her and Ismail Khan's fake passports had come out. I have got nothing to do with these reports. I don't know why he dragged me into all this," he added.
Sahil also claims that he was threatened for his life by Ismail.
(With additional information from PTI)